TY  - JOUR
T1  - An Overview on Sodium Imbalance from an Emergency Physician Perspective
A1  - Omamah Hassan Al-Jefri
A1  - Manal Khalaf Alzahrani
A1  - Jamal Ahmed Almarshadi
A1  - Hatim Osama Alhelali
A1  - Mohammed Abdullah A Albariqi
A1  - Meshary Amer Alsairy
A1  - Anas Khalid Ali Algarni
A1  - Deema Siraj Abid
A1  - Shatha Abdulrahman Alqarni
A1  - Rawan Ahmad Albluwi
A1  - Turki Ali Mohammed Alshehri
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2021
VL  - 12
IS  - 4
DO  - 10.51847/5i0P1zJt7N
SP  - 68
EP  - 72
N2  - The body regulates the fluid concentration within the body, along with the solutes, within a narrow range by the action of multiple receptors, hormones, and organs. Sodium is the principal extracellular cation, and thus it affects the flow of water from the extracellular compartment into the intracellular compartment. Sodium imbalances can be life-threatening as they may cause cerebral edema leading to brain herniation or brain shrinkage leading to cerebral vein rupture in the cases of hyponatremia and hypernatremia, respectively. We aimed to review the literature looking into sodium imbalances, along with the acute phase management. PubMed database was used for articles selection, from where papers were obtained and reviewed. The regimen for correcting sodium imbalances depends on multiple factors, including the severity of the symptoms, the concentration of serum sodium, and the patients’ risk factors. This is put to avoid overcorrection and its complications. In the case of hyponatremia, overcorrection may lead to osmotic demyelination syndrome. As for hypernatremia, over-correction may lead to cerebral herniation. It is imperative to know the rate for correction and the etiologies for sodium imbalances as they are the cornerstone of therapy in the acute phase.
UR  - https://pharmacophorejournal.com/article/an-overview-on-sodium-imbalance-from-an-emergency-physician-perspective-trciz5cogexlk5c
ER  -