TY  - JOUR
T1  - Assessment of Cytotoxic Activity Towards PC3 Cell Line of Peptide Esters of Galantamine: GAL-LEU and GAL-VAL
A1  - Dobrina Tsvetkova
A1  - Lyubomir Vezenkov
A1  - Tchavdar Ivanov
A1  - Dancho Danalev
A1  - Ivanka Kostadinova
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2023
VL  - 14
IS  - 2
DO  - 10.51847/1uNNypZfX2
SP  - 111
EP  - 119
N2  - The current work's objective was to examine the cytotoxic activity of recently created peptide esters of Galantamine: GAL-LEU and GAL-VAL on prostate cancer PC3 cell lines. For the estimation of the cytotoxic effect of Galantamine derivatives, the MTT reduction assay was applied. PC3 cells were triplicate exposed separately to each of the peptide esters, applied in different concentrations (1.875 mМ ÷ 30 mМ). In the MTT test, the reduction of tetrazolium salt MTT resulted in the creation of formazan, whose absorbance was measured spectrophotometrically at wavelength 570 nm. The experimental results show that peptide ester GAL-LEU at 30 mM inhibits 55.36% of PC3 cell growth with an index of cell viability of 44.64 %. The lower antiproliferative effect of derivative GAL-VAL was proven by the fact that 30 mM inhibits 43.96 % of cell growth. The results showed that both of the tested esters had cytotoxic action against the PC3 cell line, but that GAL-LEU has a stronger antiproliferative impact than GAL-VAL (IC50 >30 mM), because of its lower value of IC50 = 30.8 mM.
UR  - https://pharmacophorejournal.com/article/assessment-of-cytotoxic-activity-towards-pc3-cell-line-of-peptide-esters-of-galantamine-gal-leu-and-yzs1mv0uq5etu5q
ER  -