TY - JOUR T1 - Characterization in Terms of Phytochemical Content and Medicinal Potential of the Stellaria media Plant Extract A1 - Florina Groza Miere A1 - Mariana Ganea A1 - Andrei George Teodorescu A1 - Tunde Horvath A1 - Alina Hanga-Farcas A1 - Nagy Csaba A1 - Marcel Zdinca A1 - Mihaela Zdinca A1 - Luciana Dobjanschi JF - Pharmacophore JO - Pharmacophore SN - 2229-5402 Y1 - 2023 VL - 14 IS - 1 DO - 10.51847/qfiILPQ13P SP - 45 EP - 55 N2 - In this paper, the Stellaria media plant, which is part of the Caryophyllaceae family, is highlighted from the point of view of its chemical composition through qualitative and quantitative methods such as Folin-Ciocalteu and HPLC-DAD_ESI for highlighting the total phenols. The biomedical properties were also tested, such as the antioxidant capacity through the DPPH and TEAC methods, the antimicrobial capacity compared to different antibiotics on E. coli and S. aureus, but also the cicatrizing capacity in vitro on normal human dermal fibroblast-type cells of the plant extract under two forms of application (extract 1 mg/ml respectively its liposomal form) compared to the positive control (liposomes without extract included and 50 mg/ml alanine) and negative control (untreated in vitro simulated wound). To be able to apply the liposomal formula with included extract on NHDF cells, liposomes were formulated using cholesterol and phosphatidylserine in a ratio of 2:3 by the lipid film hydration method (with phosphate buffer pH 7.6). The liposomal formula was characterized by microscopy, DLS analysis, and Extract Inclusion Efficiency (EE%). Last but not least, the samples applied to highlight the cicatrizing effect were tested by the MTS method regarding their toxicity on fibroblast cells. UR - https://pharmacophorejournal.com/article/characterization-in-terms-of-phytochemical-content-and-medicinal-potential-of-the-stellaria-media-pl-qjy0nmm4f9vyf8o ER -