TY  - JOUR
T1  - Chemical Constituents from the Seeds of Alpinia blepharocalyx K. Schum in Vietnam and their Bioactives
A1  - Ngoc-Tuan Nguyen
A1  - Thi-Huong Nguyen
A1  - Trung-Hieu Tran
A1  - Thanh-Huyen Mai Thi
A1  - Nu-Trinh Nguyen Thi
A1  - Xuan-Hai Tang
A1  - Viet-Hai Ha
A1  - Gia-Buu Tran
A1  - Dinh-Thang Tran
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2020
VL  - 11
IS  - 6
SP  - 108
EP  - 111
N2  - Introduction: Today, Alpinia plants are used to treat many diseases such as enterozoa, vomiting, gastralgia, indigestion, etc. in Japan, China, and India. The main second metabolites compounds of Alpinia were terpenoids, steroids, alkaloids, diarylheptanoids, flavanones, etc. As a continued program aiming to search for new metabolites from the Alpinia plants, A. blepharocalyx K. Schum. was collected and studied. Materials & Methods: This study aimed to isolate the bioactive compounds from the seeds of Alpinia blepharocalyx K. Schum (SAB) and evaluate their anti-cancer and anti-inflammatory effects in Vietnam. The compounds of SAB were determined via MS, IR, and NMR spectrum analysis, and their anticancer activity was tested against cancer cell lines (KB, SK-LU-1, MCF7, and HepG2) via the MTT assay. Moreover, the anti-inflammatory effect of the compounds was measured by evaluating the elastase release inhibition and the assays of the superoxide anion generation.  Results & Discussion: We identified a sesquiterpene (alpiblepharin A) and eight flavonoids (flavokawain A, 2', 6'-dihydroxy-4'-metoxychalcone, nevadensin, apigenin, apigetrin, cynaroside, rutin, polydatin) from the SAB extract. This compounds showed significant anti-inflammatory (IC50 values of 4.3 ± 0.3 and 6.3 ± 1.7 μM) and cytotoxic activity (IC50 values of 15.23 ± 2.14 - 25.81 ± 2.45 μM/mL) against cancer cell lines (KB, SK-LU-1, MCF7, and HepG2).  Conclusion: The data suggested Alpinia blepharocalyx K. Schum. as a promising functional food for the treatment of inflammatory and cancer-related diseases.
UR  - https://pharmacophorejournal.com/article/chemical-constituents-from-the-seeds-of-alpinia-blepharocalyx-k-schum-in-vietnam-and-their-bioactives
ER  -