TY  - JOUR
T1  - Development of Vaginal Suppositories Modified with Silver Nanoparticle
A1  - Diana Abdulovna Yakubova
A1  - Hava Said-Selimovna Arsanukayeva
A1  - Iman Anvarovna Zakaeva
A1  - Zaira Ikramovna Nukhova
A1  - Kamila Teimurovna Sargulanovna
A1  - Elina Beslanovna Dadaeva
A1  - Madina Vakhaevna Mutsaeva
A1  - Tahmina Teyub Kyzy Hasanova
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2024
VL  - 15
IS  - 2
DO  - 10.51847/uZV70TmXhl
SP  - 119
EP  - 123
N2  - The article presents the results of a study on the development of vaginal suppositories with silver nanoparticles. The composition of excipients was selected, the main parameters of the technological process were determined: the temperature of preparation of the suppository mass, the time of dispersion of the substance, the conditions and cooling time. It was found that the use of Macrogol 4000 in suppositories with poviargol is difficult, since the temperature of their preparation is lower than the solidification temperature of the auxiliary substance. The optimal composition and the temperature regime of preparation of suppositories (≤40-42 oC) were selected. It is shown that the experimental and semi-industrial series of suppositories fully comply with the developed specifications. They have deviations from the nominal weight value of no more than 0.63%, deviations from the nominal content of poviargol no more than 3.34%, acceptable decay time and microbiological purity. A wide antimicrobial spectrum of action of suppositories in relation to gram-negative, gram-positive microorganisms and fungi was identified.
UR  - https://pharmacophorejournal.com/article/development-of-vaginal-suppositories-modified-with-silver-nanoparticle-cq5g8zipmsbmzox
ER  -