TY  - JOUR
T1  - Estimation of Quality Characteristics for Sustained Releasing and Acting Formulation of Domperidone
A1  - Z Zeb-un-Nisa
A1  - Syed Imran Ali
A1  - Saira Shahnaz
A1  - Tayyaba Mumtaz
A1  - Muhammad Mustafa Swaleh
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2021
VL  - 12
IS  - 1
DO  - 10.51847/ybCXGWy0fS
SP  - 57
EP  - 64
N2  - The present study aimed to design a sustained releasing and acting formulation of Domperidone with the aid of hydrophilic Methocel® K4M. Domperidone is an antiemetic drug used to treat nausea and vomiting. Generally, the dosing frequency is twice or thrice daily. Sustained- release formulation was prepared with different ratios of K4M. Furthermore, its quality and stability were determined. Pre-compression and post-compression characteristics were examined and the optimized formulation was selected for dissolution studies and also for similarity profiles. Drug dissolution studies revealed formulated tablet containing CF2 depicted the ideal release profile for once-daily consumption. Long-acting domperidone matrices were not just prepared but also displayed desirable properties required for an ideal once-daily formulation. The mechanism might be gel layer formation which afterward proceeded by gel erosion, hence giving a long slow-releasing pattern and desirable therapeutic effect. The concept of controlled release formulations helps the patients and care givers by reducing dosing frequency and chances of missed doses or overnight gap in administration of dose.
UR  - https://pharmacophorejournal.com/article/estimation-of-quality-characteristics-for-sustained-releasing-and-acting-formulation-of-domperidone-6nflzq9xfbixpkv
ER  -