TY  - JOUR
T1  - Evaluation of Cytotoxic and Cytostatic Activity of Chlorophytum comosum Methanol Extract
A1  - Murad Elshanovich Turabov
A1  - Victoria Viktorovna Kolesnikova
A1  - Aziza Rasulovna Bazaeva
A1  - Dina Bislanovna Dzukheraeva
A1  - Vladimir Vladimirovich Ternovoy
A1  - Aleksandr Dmitrievich Kompaneec
A1  - Viktoria Aleksandrovna Zhiteneva
A1  - Vera Arturovna Medvedeva
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2024
VL  - 15
IS  - 4
DO  - 10.51847/D5CauwttEJ
SP  - 33
EP  - 38
N2  - Chlorophytum comosum leaf extract is well-known to contain flavonoids. The extract has cytotoxic and cytostatic activity in normal animal cells. At concentrations of 15 mg/mL and above, the extract leads to 100% death of SPEV cells. The number of dead cells of the SPEV line generally increases with increasing extract concentration. The LC50 of Chlorophytum comosum extract was determined by probit analysis (LC50 = 7.24 mg/mL). With an increase in the concentration of the extract, a noticeable decrease in the proliferative activity of cells was observed. After 48 hours, the inhibition of proliferative activity of SPEV cells is more pronounced than after 24 hours. The percentage of SPEV cells that died under the action of Chlorophytum comosum extract becomes smaller with increasing exposure time.  The results of the analysis of the tumor mass at the end of the experiment fully correspond to the dynamics of its growth. The data obtained by us indicate the absence of the effect of Chlorophytum comosum extract against the transferable liver cancer of rats in an in vivo experiment.
UR  - https://pharmacophorejournal.com/article/evaluation-of-cytotoxic-and-cytostatic-activity-of-chlorophytum-comosum-methanol-extract-powo9emjbrxpipn
ER  -