TY  - JOUR
T1  - Factors Predicting the Risk of Ventricular Arrhythmias in Patients with Mitral Valve Prolapse
A1  - Tudoran Cristina-
A1  - Florica Voiță-Mekeres
A1  - Ioan Bogdan Voiță
A1  - Paula Marian
A1  - Alin Ovidiu Petriș
A1  - Larisa Bianca Galea-Holhoș
A1  - Adrian Osiceanu
A1  - Mariana Tudoran
A1  - Bianca Neli Burtă
A1  - Radu Fodor
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2023
VL  - 14
IS  - 3
DO  - 10.51847/iL4JRSY5Mu
SP  - 65
EP  - 70
N2  - Mitral valve prolapse (MVP) has an incidence ranging from 2 to 3%. It is usually a benign condition, but it can be associated with an increased risk of ventricular arrhythmias (VA) leading to sudden cardiac death (SDC). Our study aimed to evidence to victims of SDC, the incidental presence of MVP, and the associated histological alterations. In patients with MVP, we assessed the increased risk for VA, by studying the Heart Rate Variability (HRV) and Heart Rate Turbulence (HRT). Firstly, in 2021, we conducted a morpho-pathological study on 225 victims of SDC, and concomitantly, a clinical study was performed on 50 patients with MVP who underwent 24 hours Holter monitoring. In the first study, we evidenced in 8 subjects, alterations of the mitral valve (MV) suggestive of MVP, and associated with fibrotic lesions in the vicinity of MV. The patients included in the clinical study were divided into two groups based on age, clinical particularities, and 2D-echocardiographic aspect: group A: 23 subjects younger than 40 years with myxomatous degeneration of the MV and group B, 27 elderly patients with MVP and associated cardiovascular pathology. In patients with MVP, 24-hour Holter monitoring may evidence alterations of HRV and HRT, frequently related to the severity of mitral regurgitation (MR), which could explain the increased risk for VA.
UR  - https://pharmacophorejournal.com/article/factors-predicting-the-risk-of-ventricular-arrhythmias-in-patients-with-mitral-valve-prolapse-fncym0lldivgbig
ER  -