%0 Journal Article
%T Formulation and Characterization of Hydrophilic Ointment Bases with Carvacrol and Magnolol for Periodontal Application
%A Georgiana Ioana Potra Cicalău
%A Florina Miere
%A Amit Kumar Mandal
%A Mariana Ganea
%A Ioana Scrobota
%A Gabriela Ciavoi
%A Claudia Maria Jurca
%J Pharmacophore
%@ 2229-5402
%D 2022
%V 13
%N 2
%R 10.51847/A7vNt1HX00
%P 26-32
%X Nowadays, bacterial resistance to classical drugs (antibiotics) is increasingly mentioned in the literature. The same situation is presented in the case of bacteria in the oral cavity, so there is an acute need to formulate new preparations with antibacterial or even anti-inflammatory or antioxidant action. The need for these innovative preparations has increased the attention on plant compounds. Thus, this paper brings to the fore hydrogel-type formulations that are strongly compatible with the oral mucosa and contain active substances with antibacterial, anti-inflammatory and antioxidant properties such as magnolol and carvacrol. The hydrogel was designed in four types of formulas that differ in the type of active substance but also in the added polymer concentration.
The gels formed were characterized from an organoleptic point of view, stability and rheological properties. The analysis showed that the gels obtained conform to the known standards and have a different viscosity due to the polymer added in different concentrations (0.5% and 1%). Thus, in the future perspective, we want to highlight the influence of the hydrogel base in the release of the active substance respectively to test in vivo the antibacterial, anti-inflammatory and antioxidant activity of the designed oral hydrogel.
%U https://pharmacophorejournal.com/article/formulation-and-characterization-of-hydrophilic-ointment-bases-with-carvacrol-and-magnolol-for-perio-ahcjmoe5aprkzaj