%0 Journal Article %T Hibiscus sabdariffa Leaf Extract Activates Molecular Gene Expressions of Insulin and GLP-I Receptor in Streptozotocin-Induced Rats %A Basiru Olaitan Ajiboye %A Courage Dele Famusiwa %A Adetutu Omolola Ojelabi %A Waliu Olalekan Akinola %A Elijah Toluwase Adeyemi %A Adedeji A. Adejumo %A Olutunmise Victoria Owolabi %A Temitope Olawale Jeje %A Fisayo Abraham Bamisaye %A Babatunde Emmanuel Oyinloye %A Sara Vitalini %A Marcello Iriti %J Pharmacophore %@ 2229-5402 %D 2024 %V 15 %N 5 %R 10.51847/xSFzqq25OY %P 15-26 %X This work investigated the therapeutic effects of flavonoid-rich extracts obtained from Hibiscus sabdariffa L. leaves in streptozotocin-induced diabetic rats. Their biochemical parameters such as redox stress biomarkers, anti-inflammatory levels, pancreatic histology, insulin concentration, lipase activity, purinergic enzyme activities, homeostasis model assessment of β-cells (HOMA-β), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed. Furthermore, the relative gene expressions of insulin receptors and GLP-1 were examined. H. sabdariffa extracts significantly (p %U https://pharmacophorejournal.com/article/hibiscus-sabdariffa-leaf-extract-activate-molecular-gene-expressions-of-insulin-and-glp-i-receptor-i-yvpqjqguxwahau7