%0 Journal Article
%T Hibiscus sabdariffa Leaf Extract Activates Molecular Gene Expressions of Insulin and GLP-I Receptor in Streptozotocin-Induced Rats
%A Basiru Olaitan Ajiboye
%A Courage Dele Famusiwa
%A Adetutu Omolola Ojelabi
%A Waliu Olalekan Akinola
%A Elijah Toluwase Adeyemi
%A Adedeji A. Adejumo
%A Olutunmise Victoria Owolabi
%A Temitope Olawale Jeje
%A Fisayo Abraham Bamisaye
%A Babatunji Emmanuel Oyinloye
%A Sara Vitalini
%A Marcello Iriti
%J Pharmacophore
%@ 2229-5402
%D 2024
%V 15
%N 5
%R 10.51847/xSFzqq25OY
%P 15-26
%X This work investigated the therapeutic effects of flavonoid-rich extracts obtained from Hibiscus sabdariffa L. leaves in streptozotocin-induced diabetic rats. Their biochemical parameters such as redox stress biomarkers, anti-inflammatory levels, pancreatic histology, insulin concentration, lipase activity, purinergic enzyme activities, homeostasis model assessment of β-cells (HOMA-β), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed. Furthermore, the relative gene expressions of insulin receptors and GLP-1 were examined. H. sabdariffa extracts significantly (p
%U https://pharmacophorejournal.com/article/hibiscus-sabdariffa-leaf-extract-activate-molecular-gene-expressions-of-insulin-and-glp-i-receptor-i-yvpqjqguxwahau7