TY - JOUR T1 - Hibiscus sabdariffa Leaf Extract Activates Molecular Gene Expressions of Insulin and GLP-I Receptor in Streptozotocin-Induced Rats A1 - Basiru Olaitan Ajiboye A1 - Courage Dele Famusiwa A1 - Adetutu Omolola Ojelabi A1 - Waliu Olalekan Akinola A1 - Elijah Toluwase Adeyemi A1 - Adedeji A. Adejumo A1 - Olutunmise Victoria Owolabi A1 - Temitope Olawale Jeje A1 - Fisayo Abraham Bamisaye A1 - Babatunde Emmanuel Oyinloye A1 - Sara Vitalini A1 - Marcello Iriti JF - Pharmacophore JO - Pharmacophore SN - 2229-5402 Y1 - 2024 VL - 15 IS - 5 DO - 10.51847/xSFzqq25OY SP - 15 EP - 26 N2 - This work investigated the therapeutic effects of flavonoid-rich extracts obtained from Hibiscus sabdariffa L. leaves in streptozotocin-induced diabetic rats. Their biochemical parameters such as redox stress biomarkers, anti-inflammatory levels, pancreatic histology, insulin concentration, lipase activity, purinergic enzyme activities, homeostasis model assessment of β-cells (HOMA-β), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed. Furthermore, the relative gene expressions of insulin receptors and GLP-1 were examined. H. sabdariffa extracts significantly (p UR - https://pharmacophorejournal.com/article/hibiscus-sabdariffa-leaf-extract-activate-molecular-gene-expressions-of-insulin-and-glp-i-receptor-i-yvpqjqguxwahau7 ER -