TY  - JOUR
T1  - Impact of Shelves’ Storage Conditions on Degradation of Co-Amoxiclav ‎
A1  - Saba Shaikh
A1  - Mirza T. Baig
A1  - Shumaila Shaikh
A1  - Uzma Shahid
A1  - Ambreen Huma
A1  - Saira Shahnaz
A1  - Sadaf Ibrahim
A1  - Aisha Jabeen
A1  - Nayel Syed
A1  - Samina Sheikh
A1  - Hirra Soomro
A1  - Shahzada A. Khan
A1  - Arva Rawat
A1  - Mehwish M. Ali
A1  - Rasheeda Fatima
A1  - Faryal Hassan
A1  - Muhammad N. Toor
A1  - Ahmed S. Mirza
A1  - Javeria M. Arif
A1  - Aslam Shah
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2020
VL  - 11
IS  - 4
SP  - 65
EP  - 70
N2  - Stability is the ability of a drug substance or drug product to persist within the established specifications, to sustain its physicochemical and pharmacological properties throughout its shelf life. Drugs can be degraded when exposed to conditions that are not suitable or labeled for it. Co-amoxiclav (amoxicillin-clavulanate potassium) samples of 7 brands (Amoxicillin: 125mg/5ml, Clavulanic Acid: 31.25mg/5ml) were evaluated to determine the parameters such as physical description (color, odor, and taste), pH, water content, and drug content analysis at days 0, 15, 30 and 45. The results showed that most of the variations were observed at day 45 of the storage of the drug product. It was concluded that the storage conditions at pharmacies/ medical stores are not fulfilling the regulatory guidelines which contributed to degrading the drug content of co-amoxiclav dry powder for suspension for oral utilization.
UR  - https://pharmacophorejournal.com/article/impact-of-shelves-storage-conditions-on-degradation-of-co-amoxiclav
ER  -