%0 Journal Article
%T In-Vitro Study of the Properties of Components for the Synthesis of Sorbent for Low-Density Lipoprotein Apheresis
%A Anna Andreevna Bazhenova
%A Natalia Igorevna Guryanova
%A Gleb Sergeevich Guryanov
%A Heda Abdul Vahidovna Alieva
%A Diana Tamerlanovna Kachmazova
%A Alesya Alexandrovna Khripunova
%A Sergey Nikolaevich Povetkin
%J Pharmacophore
%@ 2229-5402
%D 2021
%V 12
%N 3
%R 10.51847/BsjhKFW0Kd
%P 37-41
%X The research was carried out based on the Stavropol State Medical University. This work aimed to study the fundamental possibility of creating an immunosorbent for LDL apheresis based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies. In the course of the study, a matrix was selected for the synthesis of an immunosorbent based on aerosil modified with dextran. Affinity-purified rabbit polyclonal antibodies to human apolipoprotein B (ApoB) were immobilized onto the matrix. The obtained sample of the immunosorbent under in-vitro conditions showed good sorption properties to LDL, which makes it promising for further work on the creation of a sorbent for LDL-apheresis. It is concluded that the fundamental possibility of creating an immunosorbent based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies has been shown, which makes it possible to effectively bind and remove LDL from the blood plasma.
%U https://pharmacophorejournal.com/article/in-vitro-study-of-the-properties-of-components-for-the-synthesis-of-sorbent-for-low-density-lipoprot-cz5ftrofdixvpgs