TY  - JOUR
T1  - In-Vitro Study of the Properties of Components for the Synthesis of Sorbent for Low-Density Lipoprotein Apheresis
A1  - Anna Andreevna Bazhenova
A1  - Natalia Igorevna Guryanova
A1  - Gleb Sergeevich Guryanov
A1  - Heda Abdul Vahidovna Alieva
A1  - Diana Tamerlanovna Kachmazova
A1  - Alesya Alexandrovna Khripunova
A1  - Sergey Nikolaevich Povetkin
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2021
VL  - 12
IS  - 3
DO  - 10.51847/BsjhKFW0Kd
SP  - 37
EP  - 41
N2  - The research was carried out based on the Stavropol State Medical University. This work aimed to study the fundamental possibility of creating an immunosorbent for LDL apheresis based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies. In the course of the study, a matrix was selected for the synthesis of an immunosorbent based on aerosil modified with dextran. Affinity-purified rabbit polyclonal antibodies to human apolipoprotein B (ApoB) were immobilized onto the matrix. The obtained sample of the immunosorbent under in-vitro conditions showed good sorption properties to LDL, which makes it promising for further work on the creation of a sorbent for LDL-apheresis. It is concluded that the fundamental possibility of creating an immunosorbent based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies has been shown, which makes it possible to effectively bind and remove LDL from the blood plasma.
UR  - https://pharmacophorejournal.com/article/in-vitro-study-of-the-properties-of-components-for-the-synthesis-of-sorbent-for-low-density-lipoprot-cz5ftrofdixvpgs
ER  -