%0 Journal Article
%T Microrna-21 and the Role of Anti-Apoptosis in Human Cancers
%A Minh Trong Quang
%A Kim My Thi Le
%A Tung Thanh Nguyen
%A Trinh Viet Nguyen
%A Tran Que Thi Tran
%A Hue Hong Thieu
%A Thuy Ai Huyen Le
%A Thuan Duc Lao
%J Pharmacophore
%@ 2229-5402
%D 2020
%V 11
%N 3
%P 78-81
%X The dysregulation of miR-21 has been defined as the genome instability, an event of the hallmarks of cancer, is observed in human cancers. Additionally, the effect of dysregulation of miR-21 was observed in its target genes, which is involved in many signal pathways of tumorigenesis. Among them, particularly, miR-21 is strongly involved in the anti-apoptosis processes, also known as evading apoptosis. In the present study, we studied the experimentally validated miR-21 targets, including Bcl-2, PTEN, and PDCD4 gene, which are linked to anti-apoptosis in human cancers. Thus, miR-21 and its targeting apoptosis is a valuable therapeutic target in the development of human cancer treatment.
%U https://pharmacophorejournal.com/article/microrna-21-and-the-role-of-anti-apoptosis-in-human-cancers