TY  - JOUR
T1  - Microrna-21 and the Role of Anti-Apoptosis in Human Cancers
A1  - Minh Trong Quang
A1  - Kim My Thi Le
A1  - Tung Thanh Nguyen
A1  - Trinh Viet Nguyen
A1  - Tran Que Thi Tran
A1  - Hue Hong Thieu
A1  - Thuy Ai Huyen Le
A1  - Thuan Duc Lao
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2020
VL  - 11
IS  - 3
SP  - 78
EP  - 81
N2  - The dysregulation of miR-21 has been defined as the genome instability, an event of the hallmarks of cancer, is observed in human cancers. Additionally, the effect of dysregulation of miR-21 was observed in its target genes, which is involved in many signal pathways of tumorigenesis. Among them, particularly, miR-21 is strongly involved in the anti-apoptosis processes, also known as evading apoptosis. In the present study, we studied the experimentally validated miR-21 targets, including Bcl-2, PTEN, and PDCD4 gene, which are linked to anti-apoptosis in human cancers. Thus, miR-21 and its targeting apoptosis is a valuable therapeutic target in the development of human cancer treatment.
UR  - https://pharmacophorejournal.com/article/microrna-21-and-the-role-of-anti-apoptosis-in-human-cancers
ER  -