TY  - JOUR
T1  - Novel Topical Formulations Based on O. Basilicum and T. Pratense : Antioxidant, Antimicrobial, and Anti-Inflammatory Effect
A1  - Andreea-Ina Mintas Antonescu
A1  - Angela Antonescu
A1  - Florina Groza Miere
A1  - Luminita Fritea
A1  - Andrei George Teodorescu
A1  - Laura Vicas
A1  - Ilarie Brihan
A1  - Maria Domuta
A1  - Mihaela Zdrinca
A1  - Marcel Zdrinca
A1  - Luciana Dobjanschi
A1  - Mariana Ganea
A1  - Simona Cavalu
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2022
VL  - 13
IS  - 4
DO  - 10.51847/c9XdRSVT7W
SP  - 80
EP  - 90
N2  - This study aimed to highlight the importance of phytochemical-based formulations in the treatment of wounds with different etiologies, avoiding the possible side effects generated by conventional treatments. We present the preparation method of novel topical formulations (cream, ointment, and hydrogel) based on mixed extracts of Ocimum basilicum and Tifolium pratense along with evidence of their antimicrobial and antioxidant effect in vitro. The anti-inflammatory and wound healing properties of the new formulations were evaluated against different chronic inflammatory processes by presenting three clinical cases of chronic skin diseases. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of dyshidrotic eczema, ointment formulation in the case of hypertrophic scar, and hydrogel formulation in the case of psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques.
UR  - https://pharmacophorejournal.com/article/novel-topical-formulations-based-on-o-basilicum-and-t-pratense-antioxidant-antimicrobial-and-an-znomisny7ktfbxr
ER  -