TY  - JOUR
T1  - Stabilization of Physiological Saline Solutions for Injection by Low-Frequency Acoustic Treatment
A1  - A S Magamadov
A1  - M I V Chuchaev
A1  - D R Baragunova
A1  - I A Sokurov
A1  - A V Sklyuev
A1  - D Berthold
A1  - M P Marinicheva
A1  - E V Svetlakova
A1  - O A Baklanova
A1  - A E Mishvelov
A1  - S N Povetkin
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2021
VL  - 12
IS  - 1
DO  - 10.51847/OUpeKBPC8u
SP  - 30
EP  - 37
N2  - Despite the large range of ready-made medicines, the extemporal formulation has not lost its significance. One of the most significant extemporal dosage forms in providing, including emergency medical care, is solutions for injection, which have technological features of manufacturing. The article presents the results of a study of the main properties of water during low-frequency acoustic treatment for the preparation of stable saline solutions. Methods of stabilization of solutions for injection were studied. The effect of low-frequency acoustic treatment on the physical and chemical properties of osmotic water has been experimentally confirmed. Using computed quantum and chemical modeling, the most probable forms of water nanoclusters formed during low-frequency acoustic treatment are determined. Prospects of using the low-frequency acoustic treatment in the Pharmaceutical Industry and pharmacies to stabilize saline solutions for injection are shown. Further research will be related to the treatment of real physiological solutions of drugs with different molecular weights.
UR  - https://pharmacophorejournal.com/article/stabilization-of-physiological-saline-solutions-for-injection-by-low-frequency-acoustic-treatment
ER  -