%0 Journal Article
%T Study of the Toxicity of the Drug Monizen® Forte
%A Engasheva Ekaterina Sergeevna
%A Dorozhkin Vasily Ivanovich
%A Pavlenko Galina Ivanovna
%A Volkov Alexey Anatolievich
%A Nikanorova Anna Mikhailovna
%J Pharmacophore
%@ 2229-5402
%D 2021
%V 12
%N 2
%R 10.51847/3BCqGpJb61
%P 66-70
%X The article presents the results of studying the acute toxicity of the drug Monizen® forte with the intragastric and subcutaneous route of administration to white male mice. Determination of the parameters of acute toxicity of the drug MONIZEN® forte was carried out in the laboratory of pharmacology and toxicology and vivarium of VNIIVSGE-a branch of the FGBNU FNC VIEW RAN. Toxicological studies were carried out according to the «Guidelines for conducting preclinical studies of drugs. Part one» (2012.

The LD50 value of MONISEN® forte when administered parenterally (subcutaneously) to white nonlinear mice was 2524 ± 91.5 mg/kg and when administered orally (intragastrically) was 953.82 ± 156 mg/kg. According to the parameters of acute toxicity, established in mice, under the conditions of a single injection into the stomach, MONIZEN® forte, according to the generally accepted hygienic classification GOST 12.1.007-76, belongs to the 3rd hazard class of moderately toxic compounds. The administration of overestimated doses of the drug MONIZEN® forte white to nonlinear mice both parenterally and orally causes hepatotoxic and nephrotoxic effects.
%U https://pharmacophorejournal.com/article/study-of-the-toxicity-of-the-drug-monizen-forte-iaje1fqhodhy1ra