TY  - JOUR
T1  - The Effect of a Prolonged High-Fat Diet on the Processes of Cerebral Circulation
A1  - Ruslan Robertovich Botashev
A1  - Oksana Olegovna Dyshekova
A1  - Olga Vyacheslavovna Ubushaeva
A1  - Georgy Eduardovich Zangionov
A1  - Zalina Rustemovna Gadaborsheva
A1  - Lyana Barasbievna Daurova
A1  - Diana Beslanovna Kodzokova
A1  - Timur Sultanovich Kardanov
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2024
VL  - 15
IS  - 3
DO  - 10.51847/x7tEhnrlDB
SP  - 20
EP  - 26
N2  - In the current scientific work, violations of the cerebral circulation of laboratory animals with diabetes mellitus and metabolic syndrome have been studied. Changes in the density of the vascular network of the pial membrane of the sensorimotor cortex, dilation of the pial arteries, tissue perfusion, and oxygen saturation were considered. The studied rats were kept on a high-fat diet for 60 days, as a result of which the animals had an increase in blood glucose levels, the development of insulin resistance, and a significant set of visceral fat. The metabolic syndrome led to changes in cerebral circulation, tissue perfusion decreased by 22%, and oxygen saturation decreased by 6%. The development of type 2 diabetes mellitus leads to dysfunction of the endothelium of the cerebral arteries: the smaller the diameter of the vessel, the worse the expansion reaction to acetylcholine. It was found that the emptying of the vascular bed, and impaired reactivity of the cerebral arteries negatively affect the supply of oxygen to brain tissues.
UR  - https://pharmacophorejournal.com/article/the-effect-of-a-prolonged-high-fat-diet-on-the-processes-of-cerebral-circulation-npm3jpix7bfy3lg
ER  -