TY  - JOUR
T1  - The Quick Method for Obtaining Microcapsules with  Magnolia officinalis  Oil Included and Its Application in the Medical Field
A1  - Mariana Ganea
A1  - Tunde Horvath
A1  - Csaba Nagy
A1  - Anamaria Aurelia Morna
A1  - Priscilla Pasc
A1  - Ariana Szilagyi
A1  - Gheorghe Szilagyi
A1  - Ioan Sarac
A1  - Adrian Cote
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2024
VL  - 15
IS  - 2
DO  - 10.51847/83Wyrb1MCv
SP  - 16
EP  - 24
N2  - Magnolia officinalis is a tree whose parts (bark, leaves, flowers) are characterized by a content-rich in phytochemical compounds of great interest nowadays. Modern medicine relies on the replacement of conventional treatments or the completion of treatment schemes with plant extracts rich in different phytochemical classes for greater efficiency and to reduce side effects. In this work, the oil was extracted from the leaves of Magnolia officinalis, which was characterized by GC-MS, highlighting the majority of compounds from the class of monoterpenes (linalool and linalool derivatives) and sesquiterpenes (caryophyllene). These compounds have been described from the point of view of the action they can exert in different conditions, highlighting the main mechanisms of action. Magnolia officinalis leaves were also characterized by macro- and microscopic analysis. The obtained oil was tested from the point of view of antimicrobial activity on gram-positive and gram-negative bacteria and was included in biocompatible capsules through a quick and cheap method called the coacervation method. The need to encapsulate the oil is given by the fact that the properties of Magnolia oil are lost over time if it is preserved as such and due to the low bioavailability in the case of oral administration, the encapsulated form solves all these inconveniences. Future perspectives are related to testing the bioavailability of the encapsulated Magnolia oil by oral administration of the capsules and testing their properties over time during storage.
UR  - https://pharmacophorejournal.com/article/the-quick-method-for-obtaining-microcapsules-with-magnolia-officinalis-oil-included-and-its-applic-iexoprm8mpy4an6
ER  -