<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD with MathML3 v1.3 20210610//EN" "JATS-archivearticle1-3-mathml3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"
  dtd-version="1.3" xml:lang="en" article-type="research-article">
  <?DTDIdentifier.IdentifierValue -//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN?>
  <?DTDIdentifier.IdentifierType public?>
  <?SourceDTD.DTDName JATS-journalpublishing1.dtd?>
  <?SourceDTD.Version 1.2?>
  <?ConverterInfo.XSLTName jats2jats3.xsl?>
  <?ConverterInfo.Version 1?>
  <?properties open_access?>
  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6808</article-id>
      <article-id pub-id-type="doi">10.51847/7Qc5Z7dkCo</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A Comprehensive Review on Obsessive-Compulsive Disorder: An Update</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Ujjwal</surname>
                <given-names>Pathak</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sanjita</surname>
                <given-names>Das</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Kumar</surname>
                <given-names>Fuloria Neeraj</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Pharmacy, School of Medical and Applied Sciences, Galgotias University, Uttar Pradesh, India.
          </aff>
                  <aff id="aff2">
            <label>2</label>Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, Malaysia 08100.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="sanjita8@yahoo.co.in">sanjita8@yahoo.co.in</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>27</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <fpage>54</fpage>
      <lpage>62</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Obsessive-compulsive disorder (OCD) is a severe and intricate mental illness that profoundly impacts the lives of individuals affected by it. This comprehensive review aims to thoroughly explore all facets of OCD, encompassing its clinical presentations, prevalence as a common mental disorder, its neurological underpinnings, treatment modalities, and broader societal implications. The subsequent overview seeks to advance mental health awareness and foster empathy by integrating diverse perspectives and synthesizing existing research findings. Ongoing research endeavors are delving into the potential therapeutic uses of ketamine, known for its dissociative properties, as well as psychedelic substances in combination with psychotherapeutic interventions, as innovative approaches to treating OCD. Additionally, the utilization of mindfulness-based interventions, particularly mindfulness-based cognitive therapy (MBCT), is actively being investigated, along with the potential effectiveness of repetitive transcranial magnetic stimulation (rTMS) as an adjunct therapy for obsessive-compulsive disorders. The incidence of suicide attempts among individuals diagnosed with OCD varies widely, ranging from 6% to 51.7%, with an average occurrence of 14.2%. In this review, an updated elaboration of all aspects of the disorder has been given.</p>
      </abstract>
      <kwd-group>
                <kwd>Obsessive-compulsive disorder</kwd>
                <kwd>Serotonin</kwd>
                <kwd>Tricyclic antidepressants</kwd>
                <kwd>Pharmacology</kwd>
                <kwd>Psychotherapeutics</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>