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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6996</article-id>
      <article-id pub-id-type="doi">10.51847/8o5azELVHD</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>When Medication Recommendations Compete for Clinical Attention: A Sociotechnical Theory of Artificial Intelligence–Supported Medication Review, Pharmacist Judgment, and Action Prioritization in Complex Polypharmacy</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Berg</surname>
                <given-names>Ingrid</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Müller</surname>
                <given-names>Thomas</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Mokoena</surname>
                <given-names>Naledi</given-names>
              </name>
                              <xref rid="aff3" ref-type="aff">3</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sato</surname>
                <given-names>Kenji</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Pharmacy Practice and AI-Supported Medication Review, Norwegian School of Economics, Bergen, Norway.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Clinical Pharmacy and Sociotechnical Systems, University of Vienna, Vienna, Austria.
          </aff>
                  <aff id="aff3">
            <label>3</label>Department of Pharmacy Practice and Health Informatics, University of Cape Town, Cape Town, South Africa.
          </aff>
                  <aff id="aff4">
            <label>4</label>Department of Clinical Pharmacy and Decision Support, Keio University, Tokyo, Japan.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="ingrid.berg@nhh.no">ingrid.berg@nhh.no</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>10</month>
        <year>2026</year>
      </pub-date>
      <volume>17</volume>
      <issue>5</issue>
      <fpage>130</fpage>
      <lpage>139</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Artificial intelligence is increasingly used to identify medication-related problems, generate alerts, and support medication review, yet the clinical value of a recommendation depends on more than whether it is technically correct. In complex polypharmacy, pharmacists may confront multiple plausible recommendations while simultaneously managing incomplete information, competing tasks, verification demands, and interprofessional constraints. This article develops a sociotechnical theory of recommendation prioritization that treats clinical attention as a limited, dynamically allocated resource. The theory distinguishes recommendation generation from patient relevance, attention capture, verification, professional judgment, and eventual action. It proposes that recommendation priority emerges from interactions among expected clinical consequence, patient specificity, actionability, verification burden, temporal urgency, workflow position, and calibrated professional trust. These interactions explain why increasing recommendation volume or predictive accuracy can fail to improve medication review and may, under some conditions, displace attention from higher-value problems. Pharmacist expertise is positioned as an interpretive and coordinating capability rather than a terminal approval step. AI-supported medication review should therefore be evaluated not only by predictive performance, but also by whether it allocates attention appropriately, preserves independent verification, fits clinical workflow, and supports accountable action. The resulting account provides testable conditions under which recommendation ranking should improve, fragment, or distort medication-review work.</p>
      </abstract>
      <kwd-group>
                <kwd>Artificial intelligence</kwd>
                <kwd>Medication review</kwd>
                <kwd>Polypharmacy</kwd>
                <kwd>Pharmacist judgment</kwd>
                <kwd>Clinical decision support</kwd>
                <kwd>Professional trust</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>
