Maintaining the health of the human body and increasing the quality of life have become central elements of interest in current research. Modern medicine emphasizes the fact that the health of the body and the increase in longevity are closely related to nutrition during the individual's life. Thus, the kombucha drink represents one of the functional foods extremely rich in active bio-compounds and microorganisms that have proven to be beneficial for health. In this review, the method of obtaining the drink, its composition, and the present compounds are described in an easy-to-understand approach. The emphasis is on highlighting the multiple biological activities of this drink in distinct medical spheres, such as oxidative stress, cancer, cardiovascular diseases, dermatological diseases, antimicrobial anti-inflammatory capacity. Also described are the elements that make up this miraculous drink (substrate type, SCOBY, and added carbon source), respectively innovative elements from recent literature with reference to the replacement of the classic substrate. Finally, there are some aspects related to the contraindications of kombucha consumption; the paper ends with the conclusions.