QSAR modeling is central to computational drug discovery because it links molecular structure to biological activity before synthesis or testing. However, the practical construction of a reliable QSAR model still depends on expert judgment across data preparation, feature design, validation, and interpretation. The QSAR workflow is difficult to reproduce because each stage can involve subjective choices about chemical standardization, activity normalization, descriptor filtering, model selection, and applicability domain definition. These choices can limit the routine use of QSAR by medicinal chemists who need rapid, transparent, and fit-for-purpose predictive models. An autonomous QSAR agent would accept raw chemical–biological data together with a target endpoint specification and then execute the full modeling workflow with minimal human intervention. The agent would produce a documented predictive model, a data-quality summary, and an applicability-domain assessment suitable for decision support. The proposed system would include a data-cleaning engine, a descriptor-calculation and feature-selection module, an AutoML-based model trainer, an applicability-domain assessor, and a natural-language reporting interface. These components would operate as a coordinated workflow rather than as disconnected scripts. Such an agent could reduce routine modeling burden, enforce best-practice checks automatically, and make QSAR workflows more accessible to non-specialists. Its most important contribution would not be replacing expert judgment, but making each modeling decision traceable, reviewable, and reproducible. An autonomous QSAR agent could democratize predictive modeling in drug discovery by shifting expert effort from repetitive implementation toward strategic interpretation. The concept represents an emerging AI direction in which cheminformatics tools become active workflow participants rather than passive software components.