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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6831</article-id>
      <article-id pub-id-type="doi">10.51847/FVoKybLMM7</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Morphological Features of Osteoarthritis in Knee Arthroplasty. A Clinical Study</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Edelgirieva</surname>
                <given-names>Medina Elbekovna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Ulubaev</surname>
                <given-names>Turpal Andreevich</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Papaev</surname>
                <given-names>Khasan Bakharudinovich</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sherieva</surname>
                <given-names>Lyana Ruslanovna</given-names>
              </name>
                              <xref rid="aff3" ref-type="aff">3</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Avagyan</surname>
                <given-names>Artur Samvelovich</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Pyzhyanov</surname>
                <given-names>Vsevolod Dmitrievich</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Radeva</surname>
                <given-names>Ekaterina Alekovna</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Nikoghosyan</surname>
                <given-names>Milena Samvelovna</given-names>
              </name>
                              <xref rid="aff5" ref-type="aff">5</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Therapy, Institute of Medicine, Chechen State University, Grozny, Russia.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Dentistry, Faculty of Medicine, Astrakhan State Medical University, Astrakhan, Russia.
          </aff>
                  <aff id="aff3">
            <label>3</label>Department of Pediatrics, Faculty of Medicine, North-Ossetian State Medical Academy, Vladikavkaz, Russia.
          </aff>
                  <aff id="aff4">
            <label>4</label>Department of Therapy, F.F. Erisman Faculty of the Institute of Public Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
          </aff>
                  <aff id="aff5">
            <label>5</label>Department of Therapy, Faculty of Medicine, Saratov State Medical University named after V.I.Razumovsky, Saratov, Russia.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="ruslankalmykov777@yandex.ru">ruslankalmykov777@yandex.ru</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>20</day>
        <month>06</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>4</issue>
      <fpage>54</fpage>
      <lpage>59</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
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            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>The regional clinic performed 187 knee replacement procedures on osteoarthritis (OA) patients. Materials were randomly selected for morphological analysis from 30 patients, 11 of whom were men and 19 of whom were women, ages 40 to 76. Of the thirty individuals that underwent morphological investigations, three (10%) had stage I OA; eight (26.7%) had stage II OA identified, and nineteen (63.3%) had stage III OA. Just one in four patients (48 individuals, or 25.7%) who received endoprosthetics had at least one round of inpatient conservative or minimally invasive surgical therapy for OA. The morphological research revealed that 11 (36.7%) of the patients who received arthroplasty had validated stage I–II OA. The conclusion is that in order to create a treatment plan for patients with osteoarthritis (OA), an algorithm for coordinating specialists&amp;#39; interactions must be developed. This algorithm should involve therapists, orthopedists, rheumatologists, rehabilitologists, specialists in restorative medicine, and health care coordinators.</p>
      </abstract>
      <kwd-group>
                <kwd>Osteoarthritis</kwd>
                <kwd>Endoprosthetic</kwd>
                <kwd>Complications</kwd>
                <kwd>Morphological examination</kwd>
                <kwd>Histology</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>