The necessity of the development of compounds with effectiveness in therapy against infective diseases has increased in the last 3 years in connection with the spread of COVID-19. The current study aimed to summarize the pharmacological activities of metal-based organic compounds against different viral diseases, including COVID-19. A systematic literature review was carried out by using data sources in Medline, Pub Med, SCOPUS, and Science Direct. The used methods were collecting data, summarizing, and analyzing information. Antiviral properties exert metal complexes with ligands, such as: hydrazones; thiosemi-carbazones: Pt(II), Pd(II); Ga(III); Pd(II); Co(III), Ni(II), Cu(II)); fluoroquinolones, quinoline: Pd(II); phenylquinoline, phenylpyridine; tetrahydropyrimidines: Ag(I); phenanthroline: Cu(II); Valacyclovir: Cu(II)). Complexes of Zn(II). Co(II), Cu(II), Ni(II), Mg(II), Mn(II), and Zn(II) exert antiviral effects against the DNA Herpes simplex viruses HSV-1, HSV-2. Co(II), effective towards the HIV are complexes of the following metals: Au(II), Co(II), Cu(II), Fe(III), La(III), Mg(II). Ni(II), Pd(II), Pt(II), Ru(II). Against the HIV have been described to be active complexes of the following metals: Au(II), Co(II), Cu(II), Fe(III), La(III), Mg(II), Ni(II), Pd(II), Pt(II), and Ru(II). In connection with the continued spread of the severe acute respiratory syndrome – Coronavirus 2 (SARS-CoV-2), today's very actual strategy is the development of effective COVID therapeutics. The perspective trend in the creation and investigation of potential agents for the effective application towards SARS-CoV-2, are Auranofin and Cu(II), Ni(II), Mn(II), and Zn(II) complexes of Coumarin.