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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6809</article-id>
      <article-id pub-id-type="doi">10.51847/TZMD3FFmW6</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Effective Uses of Almond Seeds in Improving Immunological and Histopathological Functions in Hepatic Rats</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Mahzari</surname>
                <given-names>Ali</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Elmeged</surname>
                <given-names>Lobna Saad Mohammed Abd</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, KSA.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Home Economics-Nutrition, AL-Baha University, AlMakhwa, Saudi Arabia.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="amoosa@bu.edu.sa">amoosa@bu.edu.sa</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>27</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <fpage>63</fpage>
      <lpage>69</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Immunity is the body&amp;#39;s defense mechanism against invaders. Thus, in the event that infections manage to penetrate the skin or mucous membranes, the immune system acts as the body&amp;#39;s natural defensive mechanism. This investigation sought to determine if almond seeds may benefit hepatic rats&amp;#39; immune and histological systems. In this study, the animal was kept in a cage during the trial. Prior to the trial, for a week, the rats were housed in groups of six and given a standard diet. The first set of rats were negative normal controls (C-ve) and were given nothing except a baseline diet for twenty-eight days. The survival rats (n=24) were inoculated with carbon tetrachloride (Ccl4). There were three groups given different amounts of (5%, 10%, 15% almond seed), Nonetheless, one group was given the disease diagnosis before the experimental diet was even given. The findings revealed mostly significant differences among all groups contrasted with the C+ ve group. But no significant differences were observed between G3, and G4 for Monocell Immune Distribution (MID) and Granulocytes (GRAN). The highest recovery was in rats fed 15% almond seed powder in (WBC), (LYM), (MID), (GRAN), (IgG) and (IgM). Different doses of almond seeds are indicated for boosting immunity in hepatic cases.</p>
      </abstract>
      <kwd-group>
                <kwd>Almond seeds</kwd>
                <kwd>Immunological changes</kwd>
                <kwd>Hepatic patients</kwd>
                <kwd>Histopathological functions</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>