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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6807</article-id>
      <article-id pub-id-type="doi">10.51847/Wo07IlXueK</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Protective and Histological Effects of Kumquat ( Citrus japonica ) Extract in Rats Injected with Carbon Tetrachloride (CCl4)</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Elmeged</surname>
                <given-names>Lobna Saad Mohammed Abd</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Alshehri</surname>
                <given-names>Khulud Mohammed</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Home Economics-Nutrition, AL-Baha University, AlMakhwa, Saudi Arabia.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Biology, AL-Baha University, Baljurashi, Saudi Arabia.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="lobna@bu.edu.sa">lobna@bu.edu.sa</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>27</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <fpage>43</fpage>
      <lpage>53</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Kumquat or Japanese orange, the smallest tree of the citrus family, grows and gives the best and largest production and the sweetest of fruits in warmer regions. The kumquat has protective importance and a great treat. Several vital metabolic processes, including the delivery and digestion of nutrients, are carried out by the liver., thus we focused on This investigation sought to determine the histological and protective impacts of Kumquat extract in rats given injections of carbon tetrachloride (CCl4). The experiment was conducted in a cage for animals. Before the experiment began, all of the rats were given a baseline diet for a week. The rats were then separated into 5 groups, each with 6 rats. The first group was fed a basal diet exclusively for 28 days as a control negative (C -ve) normal group of rats. The rats of the remaining groups (n = 24 rats) were given injections of Ccl4. The groups were split into four groups, with 3 groups receiving ethanol extracts of kumquats in various levels (150, 200, and 250 mg/kg), and one group serving as a control that had the illness but didn&amp;#39;t follow the experimental diet. All hepatic rats given different diets exhibited substantial mean value declines as contrasted with the control (+) group, according to the data. As contrasted with the healthy group, group 5 had the best therapy for serum ALP to cause hepatopathy (normal rats). This research advised consuming kumquats, which may be had every day.</p>
      </abstract>
      <kwd-group>
                <kwd>Kumquat</kwd>
                <kwd>Hepatic patients</kwd>
                <kwd>Protective effect</kwd>
                <kwd>Histological effects</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>