<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD with MathML3 v1.3 20210610//EN" "JATS-archivearticle1-3-mathml3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"
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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6941</article-id>
      <article-id pub-id-type="doi">10.51847/aJmB8aq7Zf</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Embodied Artificial Intelligence Must Learn Laboratory Constraints before It Can Autonomously Conduct Pharmaceutical Experiments</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>De Luca</surname>
                <given-names>Marco</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Ferraro</surname>
                <given-names>Giulia</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Russo</surname>
                <given-names>Antonio</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Rossi</surname>
                <given-names>Elena</given-names>
              </name>
                              <xref rid="aff3" ref-type="aff">3</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Embodied AI and Laboratory Constraints, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Autonomous Experimentation and Physical Reasoning, Faculty of Pharmacy, University of Bologna, Bologna, Italy.
          </aff>
                  <aff id="aff3">
            <label>3</label>Department of Laboratory-Aware AI for Pharma, Faculty of Pharmacy, University of Florence, Florence, Italy.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="marco.deluca@unina.it">marco.deluca@unina.it</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>16</volume>
      <issue>6</issue>
      <fpage>66</fpage>
      <lpage>76</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Artificial intelligence is increasingly connected to automated synthesis, analytical instrumentation, experiment planning, and closed-loop scientific discovery. However, computational competence does not by itself establish the capacity to conduct pharmaceutical experiments. Laboratory work is embodied: every action is conditioned by equipment availability, material identity, container state, spatial reachability, procedural dependencies, timing requirements, contamination controls, hazard boundaries, measurement uncertainty, and human authority. Current autonomous-laboratory architectures demonstrate important elements of planning, robotic execution, sensing, and iterative optimization, yet these capabilities are commonly evaluated separately or summarized through narrow measures of task completion or optimization efficiency. This article develops an original design-principles construct, termed Constraint-Grounded Embodied Laboratory Intelligence, to organize the conditions under which artificial intelligence may progress from generating experimental proposals to participating in bounded pharmaceutical experimentation. The construct represents laboratory intelligence as a continuously updated relation among equipment affordances, material and sample states, executable procedures, temporal commitments, safety envelopes, epistemic provenance, perception, manipulation, adaptive execution, anomaly interpretation, and human takeover. The article argues that no single benchmark, planning score, manipulation-success measure, or model-confidence estimate can establish autonomous laboratory competence. Instead, evaluation must examine whether computational representations remain synchronized with physical laboratory conditions, whether proposed actions satisfy procedural and safety constraints, whether deviations are detected and interpreted appropriately, and whether humans can intervene before consequences become irreversible. The contribution is conceptual rather than empirically validated. Its applicability will depend on laboratory type, pharmaceutical modality, instrumentation, materials, local governance, and prospective evaluation. The proposed framework may nevertheless support more rigorous system design, reporting, comparison, and staged validation of embodied artificial intelligence for pharmaceutical research.</p>
      </abstract>
      <kwd-group>
                <kwd>Embodied artificial intelligence</kwd>
                <kwd>Autonomous laboratories</kwd>
                <kwd>Pharmaceutical experimentation</kwd>
                <kwd>Laboratory constraints</kwd>
                <kwd>Procedural grounding</kwd>
                <kwd>Adaptive execution</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>