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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6863</article-id>
      <article-id pub-id-type="doi">10.51847/bGtPljJ5Yy</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>AI Pharmacovigilance Workflow for Detecting Neurological Adverse Events from Reports, Notes, and Literature</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Park</surname>
                <given-names>Jinwoo</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Kim</surname>
                <given-names>Minji</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Lee</surname>
                <given-names>Seung</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Computational Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of AI Drug Engineering, Faculty of Engineering, KAIST, Daejeon, South Korea.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="jinwoo.park@outlook.com">jinwoo.park@outlook.com</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>06</month>
        <year>2025</year>
      </pub-date>
      <volume>16</volume>
      <issue>3</issue>
      <fpage>42</fpage>
      <lpage>52</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Neurological adverse drug events are clinically consequential and may be missed when surveillance depends on a single source of evidence. Under-reporting, delayed recognition, and fragmented documentation make these events especially challenging for conventional pharmacovigilance workflows. Potential neurological safety signals may appear separately in spontaneous reports, electronic health record notes, and published biomedical literature. A unified AI workflow is needed to connect these evidence streams in a timely, traceable, and reviewer-ready manner. This article proposes an AI pharmacovigilance workflow that ingests spontaneous reports, clinical notes, and biomedical literature, then applies transformer-based NLP to identify neurological adverse event mentions. The extracted evidence is fused into a dynamic risk score with source attribution and reviewer-facing explanations. The workflow includes data ingestion and harmonization, multi-source NLP extraction, signal fusion, disproportionality analysis, confounder-aware alerting, and a human-review dashboard. Each module is designed to preserve links between computational outputs and the original source evidence. The proposed workflow would be expected to support earlier recognition of rare neurological safety concerns by cross-validating signals across heterogeneous data streams. It could reduce unsupported alerts by distinguishing consistent multi-source evidence from isolated or ambiguous mentions. A holistic, AI-driven surveillance system could transform pharmacovigilance from a fragmented, reactive process into an integrated, proactive safety intelligence function. Its value would depend on transparent evidence handling, expert oversight, and careful validation in operational settings.</p>
      </abstract>
      <kwd-group>
                <kwd>Artificial intelligence</kwd>
                <kwd>Pharmacovigilance</kwd>
                <kwd>Neurological adverse events</kwd>
                <kwd>Natural language processing</kwd>
                <kwd>Spontaneous reports</kwd>
                <kwd>Electronic health records</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>