<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD with MathML3 v1.3 20210610//EN" "JATS-archivearticle1-3-mathml3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"
  dtd-version="1.3" xml:lang="en" article-type="research-article">
  <?DTDIdentifier.IdentifierValue -//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN?>
  <?DTDIdentifier.IdentifierType public?>
  <?SourceDTD.DTDName JATS-journalpublishing1.dtd?>
  <?SourceDTD.Version 1.2?>
  <?ConverterInfo.XSLTName jats2jats3.xsl?>
  <?ConverterInfo.Version 1?>
  <?properties open_access?>
  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6814</article-id>
      <article-id pub-id-type="doi">10.51847/d4HrIDWggY</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Preparation of a New Enterosorbent Bentorb and Determination of Its Toxicological Properties</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Arakelyan</surname>
                <given-names>Liana Araratovna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Kamentseva</surname>
                <given-names>Polina Gennadievna</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Mashakova</surname>
                <given-names>Aiza Delimkhanova</given-names>
              </name>
                              <xref rid="aff3" ref-type="aff">3</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Kolesnichenko</surname>
                <given-names>Vitaliya Vitalievna</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Karoli</surname>
                <given-names>Inna Iurevna</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Voropaev</surname>
                <given-names>Vladislav Vladimirovich</given-names>
              </name>
                              <xref rid="aff5" ref-type="aff">5</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Therapy, Faculty of Pediatrics, Stavropol State Medical University, Stavropol, Russia.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Therapy, Faculty of Pediatrics, Rostov State Medical University, Rostov-on-Don, Russia.
          </aff>
                  <aff id="aff3">
            <label>3</label>Department of Therapy, Faculty of Pediatrics, North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia.
          </aff>
                  <aff id="aff4">
            <label>4</label>Department of Therapy, Faculty of Medicine, Stavropol State Medical University, Stavropol, Russia.
          </aff>
                  <aff id="aff5">
            <label>5</label>Department of Therapy, Faculty of Medical and Preventive Medicine, Rostov State Medical University, Rostov-on-Don, Russia.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="bucky99@ya.ru">bucky99@ya.ru</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <fpage>105</fpage>
      <lpage>112</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>This article presents the results of several studies of the new Bentorb sorbent, which is produced from wine-making waste - adhesive deposits of yellow blood salt. It was found that oxygen, carbon, silicon, aluminum, iron, nitrogen, and magnesium occupy the largest percentage in the sorbent sample. Studies of the toxicological properties of Bentorb sorbent were carried out on laboratory animals. Studies of the acute toxicity of the Bentorb sorbent were conducted on 60 white mongrel rats weighing 237 ± 7 g. Experiments found that the general clinical condition of rats from all experimental and control groups did not change significantly, all animals remained alive. Studies of the chronic toxicity of Bentorb sorbent were conducted on 60 white mice and 40 Wistar rats weighing 185±12 g. During the study period, no significant differences in the general condition and survival of control and experimental animals were observed. The study of the effect of Bentorb sorbent on the function of the digestive tract was carried out on piglets 40-80 days old. The study of the effect of Bentorb sorbent on the function of the digestive tract was carried out on piglets 40-80 days old. The embryotoxic effect of Bentorb sorbent was studied on pregnant Wistar rats with an average body weight of 200-240 g. In addition, a study of body weights and some internal organs of laboratory animals, a control group, and an experimental one taking Bentorb sorbent was conducted.</p>
      </abstract>
      <kwd-group>
                <kwd>Sorbent</kwd>
                <kwd>Sorption</kwd>
                <kwd>Enterosorbent</kwd>
                <kwd>Bentorb</kwd>
                <kwd>Acute toxicity</kwd>
                <kwd>Chronic toxicity</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>