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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6955</article-id>
      <article-id pub-id-type="doi">10.51847/enwqtllm3h</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Artificial Intelligence-Enabled Drug Discovery after the Hype Cycle: A Bibliometric and Thematic Review of Twenty-Five Years of Research</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Stankova</surname>
                <given-names>Elena</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Brown</surname>
                <given-names>Christopher</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Aisyah</surname>
                <given-names>Siti</given-names>
              </name>
                              <xref rid="aff3" ref-type="aff">3</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Durand</surname>
                <given-names>Olivier</given-names>
              </name>
                              <xref rid="aff4" ref-type="aff">4</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Bibliometric and Thematic Review of AI in Drug Discovery, Faculty of Pharmacy, Karolinska Institute, Stockholm, Sweden.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of AI-Enabled Drug Discovery and Hype Cycle Analysis, Faculty of Pharmacy, University of Toronto, Toronto, Canada.
          </aff>
                  <aff id="aff3">
            <label>3</label>Department of Twenty-Five Years of AI in Pharma Research, Faculty of Pharmaceutical Sciences, National University of Malaysia, Kuala Lumpur, Malaysia.
          </aff>
                  <aff id="aff4">
            <label>4</label>Department of Post-Hype AI Translation, Faculty of Pharmacy, University of Bordeaux, Bordeaux, France.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="elena.stankova@ki.se">elena.stankova@ki.se</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>08</month>
        <year>2025</year>
      </pub-date>
      <volume>16</volume>
      <issue>4</issue>
      <fpage>62</fpage>
      <lpage>71</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>Artificial intelligence has progressed from a specialized computational aid to a prominent organizing concept across target identification, molecular screening, lead optimization, synthesis planning, drug repurposing, and development strategy. However, the visibility of the field has grown faster than the evidentiary frameworks needed to distinguish methodological novelty from pharmaceutical value. This bibliometric and thematic review examines how the research landscape should be interpreted after the most promotional phase of the AI drug-discovery discourse. The review combines a transparent dual-database corpus-construction protocol with performance analysis, science mapping, and structured thematic coding. Rather than treating publication growth, citation impact, collaboration density, or benchmark performance as direct evidence of maturity, the synthesis evaluates what each indicator can establish and where additional validation is required. The resulting interpretation separates methodological expansion from evidence maturation and distinguishes computational capability, comparative benchmark performance, external generalization, prospective experimental confirmation, developability, clinical evaluation, and routine pharmaceutical readiness. The review further proposes claim-level hype-cycle indicators based on validation realism, reproducibility, data suitability, evidence provenance, prospective confirmation, and correspondence between model endpoints and pharmaceutical decisions. Bibliometric structures are interpreted as properties of the constructed corpus rather than universal representations of the field, while thematic clusters are treated as organizing devices rather than proof of scientific coherence or translational success. Important limitations include database-dependent coverage, incomplete visibility of proprietary industrial research, terminology drift, uneven reporting of negative findings, and the difficulty of attributing program-level outcomes to individual computational components. The central implication is that the next phase of AI-enabled drug discovery should be evaluated through decision-relevant evidence, traceable data practices, realistic validation, and explicit boundaries between prediction and pharmaceutical utility.</p>
      </abstract>
      <kwd-group>
                <kwd>Artificial intelligence</kwd>
                <kwd>Drug discovery</kwd>
                <kwd>Bibliometric analysis</kwd>
                <kwd>Science mapping</kwd>
                <kwd>Thematic analysis</kwd>
                <kwd>Generative models</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>