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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6813</article-id>
      <article-id pub-id-type="doi">10.51847/hLlBL6gDPB</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Study of Pharmacological Properties and Sorption Abilities of the New Sorbent Ferbensorb</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Koshulko</surname>
                <given-names>Yulia Vladimirovna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Zvyagintseva</surname>
                <given-names>Evgenia Anatolyevna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sidenko</surname>
                <given-names>Nikolai Gennadievih</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Gashimova</surname>
                <given-names>Ekaterina Sergeevna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Bairamukova</surname>
                <given-names>Alina Muratovna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sarkitova</surname>
                <given-names>Rimma Ruslanovna</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Getezheva</surname>
                <given-names>Alina Muratovna</given-names>
              </name>
                              <xref rid="aff2" ref-type="aff">2</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Therapy, Faculty of Medicine, Stavropol State Medical University, Stavropol, Russia.
          </aff>
                  <aff id="aff2">
            <label>2</label>Department of Therapy, Faculty of Medical and Preventive Medicine, North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="bucky99@ya.ru">bucky99@ya.ru</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>28</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <fpage>98</fpage>
      <lpage>104</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
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            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>The use of sorbents helps to reduce the toxic load when toxic chemicals and radionuclides enter the body.  This article investigates the pharmacological properties of the new ferrocyanide-bentonite sorbent Ferbensorb. Ferbensorb is a composite sorbent containing potassium-iron(III) hexacyanoferrate(II), as well as bentonite, gelatin, and macro- and microelements. The article presents the results of experimental studies conducted on laboratory animals (rats and mice). Sorption activity with the introduction of cesium, sorption capacity with the introduction of strontium radionuclides, and sorption capacity with experimental associative mycotoxicosis were determined. In addition, a pathoanatomical autopsy was performed, and changes in body weight and some internal organs of the studied animals were determined, as well as the leukocyte formula. It was found that ferrocyanide-bentonite sorbent Ferbensorb significantly reduced the functional and morphological manifestations of the pathological process caused by mycotoxins ochratoxin A, fumonisin B, and zearalenone. It increased body weight gain, indicators of natural immunological resistance, which was expressed by an increase in the percentage of neutrophils in the leukoformula, an increase in the level of bactericidal and lysozyme activity of blood serum, and animal survival.</p>
      </abstract>
      <kwd-group>
                <kwd>Enterosorbent</kwd>
                <kwd>Ferrocyanide-bentonite sorbent</kwd>
                <kwd>Ferbensorb</kwd>
                <kwd>Sorption of strontium radionuclides</kwd>
                <kwd>Sorption of cesium</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>