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  <front>
    <journal-meta>
      <journal-id journal-id-type="iso-abbrev">Pharmacophore</journal-id>
      <journal-id journal-id-type="publisher-id">pharmacophorejournal.com</journal-id>
      <journal-id journal-id-type="publisher-id">Pharmacophore</journal-id>
      <journal-title-group>
        <journal-title>Pharmacophore</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2229-5402</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">pharmacophorejournal.com-6801</article-id>
      <article-id pub-id-type="doi">10.51847/p8MXvRqFBg</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Use of nanotechnology-based restorative materials for dental caries: A narrative review</article-title>
      </title-group>
                    <contrib-group>
                      <contrib contrib-type="author">
              <name>
                <surname>Nemer</surname>
                <given-names>Salman Naif Al</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                                            <xref rid="cor1" ref-type="corresp" />
                          </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sudairi</surname>
                <given-names>Mohammed Turki Al</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Sulaimani</surname>
                <given-names>Rakan Siraj Al</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                      <contrib contrib-type="author">
              <name>
                <surname>Behairy</surname>
                <given-names>Rana Mohammed</given-names>
              </name>
                              <xref rid="aff1" ref-type="aff">1</xref>
                                        </contrib>
                  </contrib-group>
                  <aff id="aff1">
            <label>1</label>Department of Dentistry, King Abdulaziz Medical City, National Guard Health Affairs Riyadh, KSA.
          </aff>
                          <author-notes>
            <corresp id="cor1">
              <bold>Address for correspondence:</bold> Prof. Wael Abu Dayyih, Department of
              Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
                              E-mail: <email xlink:href="NemerSn@ngha.med.sa">NemerSn@ngha.med.sa</email>
                          </corresp>
          </author-notes>
                    <pub-date pub-type="epub">
        <day>21</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>15</volume>
      <issue>1</issue>
      <fpage>75</fpage>
      <lpage>82</lpage>
      <permissions>
        <copyright-statement>
          Copyright: &#x000a9; 2026 Pharmacophore
        </copyright-statement>
        <copyright-year>2026</copyright-year>
        <license>
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            specific-use="textmining" content-type="ccbyncsalicense">
            https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref>
          <license-p>This is an open access journal, and articles are distributed under the terms of
            the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows
            others to remix, tweak, and build upon the work non-commercially, as long as appropriate
            credit is given and the new creations are licensed under the identical terms.</license-p>
        </license>
      </permissions>
      <abstract>
        <title>A<sc>BSTRACT</sc></title>
        <p>This review focuses on the use of state-of-the-art nanotechnology in restorative materials, presenting many innovative approaches. With an eye on improving dental caries management, our findings point to a bright future for creating novel, superior biomaterials. Dental materials have benefited from the novel use of nanotechnology, which offers the possibility of creating materials with superior qualities and antibacterial abilities. In this overview, we review the development of functional nanoparticles and their potential uses in dental restorative materials as helpful tactics for managing dental caries. Additionally, we provide an outline of the suggested remineralizing and antibacterial processes. A systematic literature review from 2000 to 2023 was performed using PubMed, Medline, and ScienceDirect databases. The keywords used were &quot;nanotechnology,&quot; &quot;dental caries,&quot; and &quot;restorative material.&quot; Nanomaterials have considerable promise in reducing the formation of biofilms, blocking the demineralization procedure, remineralizing tooth structure, and fighting microorganisms linked to dental cavities. These promising findings pave the way for further clinical research to determine the restoration products constructed using nanotechnology and their therapeutic efficacy.</p>
      </abstract>
      <kwd-group>
                <kwd>Nanotechnology</kwd>
                <kwd>Dental caries</kwd>
                <kwd>Restorative material</kwd>
                <kwd>Systematic review</kwd>
              </kwd-group>
    </article-meta>
  </front>
</article>