The article presents the results of a study on the development of vaginal suppositories with silver nanoparticles. The composition of excipients was selected, the main parameters of the technological process were determined: the temperature of preparation of the suppository mass, the time of dispersion of the substance, the conditions and cooling time. It was found that the use of Macrogol 4000 in suppositories with poviargol is difficult, since the temperature of their preparation is lower than the solidification temperature of the auxiliary substance. The optimal composition and the temperature regime of preparation of suppositories (≤40-42 oC) were selected. It is shown that the experimental and semi-industrial series of suppositories fully comply with the developed specifications. They have deviations from the nominal weight value of no more than 0.63%, deviations from the nominal content of poviargol no more than 3.34%, acceptable decay time and microbiological purity. A wide antimicrobial spectrum of action of suppositories in relation to gram-negative, gram-positive microorganisms and fungi was identified.