An epigenomic analysis is big data science, presenting tremendous challenges in its translation into knowledge. To exert precise spatiotemporal control of gene activation and repression, one must have a thorough grasp of the molecular building blocks of epigenetic processes. Only lately has the technology become available to adequately investigate the functional impact of intricate epigenetic pathways. This technology uses a combination of nuclease-null genome-editing (GE) systems and effector domains. Modern epigenome editing (EpGE) modular systems can be adapted to permit precise manipulation of epigenetic marks with no changes in underlying DNA sequence. This review briefly presents the currently achievable epigenetic manipulations along with matching applications in human food and health. The emerging era of Clustered regularly interspaced short palindromic repeats (CRISPR) EpGEs could perhaps be a game-changer for the management of chromatin and epigenetic signature an appealing strategy for therapeutic and breeding purposes. This nascent field is still suffering certain pitfalls.