TY  - JOUR
T1  - DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DIAZEPAM AND IMIPRAMINE IN BULK & PHARMACEUTICAL FORMULATIONS
A1  - Vishal Srivastava
A1  - Pradeep Kumar and R.K. Jat
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2016
VL  - 7
IS  - 1
SP  - 63
EP  - 73
N2  - A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of Diazepam and Impiramine hydrochloride, using a ODS C-18 (HIQ SIL 4.6mm x 25cm, 10μm) column and a mobile phase composed of Methanol: Phosphate buffer (75:25 v/v). The retention times of Diazepam and Impiramine hydrochloride were found to be 2.85 min and 5.24 min, respectively. Linearity was established for Diazepam and Impiramine hydrochloride in the range of 10-500 μg/ml and 2-12 μg/ml, respectively. The percentage recoveries of Diazepam and Impiramine hydrochloride were found to be in the range of 99.83-99.91% and 98.81-99.96%, respectively. Both the drugs were subjected to variance of conditions like flow rate, difference in mobile phase and concluded that this method can be successfully employed for simultaneous quantitative analysis of Diazepam and Impiramine hydrochloride in bulk drugs and formulations.
UR  - https://pharmacophorejournal.com/article/development-and-validation-of-rp-hplc-method-for-diazepam-and-imipramine-in-bulk-pharmaceutical-formulations
ER  -