TY - JOUR T1 - Effectiveness of Colistin With Rifampicin and Meropenem Against Colistin-Resistant Acinetobacter Baumannii Strains: An In Vitro Study A1 - Adriana Mosca A1 - Lidia Dalfino A1 - Federica Romanelli A1 - Stefania Stolfa A1 - Raffaele Del Prete A1 - Luigi Santacroce JF - Pharmacophore JO - Pharmacophore SN - 2229-5402 Y1 - 2020 VL - 11 IS - 2 SP - 1 EP - 6 N2 - Introduction: Antibiotic resistance is an important issue that may worsen the clinical evolution of high risks patients. The increasing use of colistin for the treatment of carbapenem-resistant Acinetobacter baumannii infections has led to the emergence of colistin resistance. Since A. baumannii is an important nosocomial pathogen and is responsible for severe infections, the use of antimicrobial combinations has been strongly recommended. Materials & Methods: This study aims to evaluate the in vitro effect of colistin/rifampicin and colistin/meropenem combinations against colistin-resistant A. baumannii isolates using two rapid E-test methods. Results: Synergy was observed with colistin in combination with rifampicin against all the isolates. Otherwise, colistin/meropenem combination showed indifference by E-test cross formation and synergy dependent by meropenem concentration by the E-test gradient. Discussion and conclusion: Nowadays A. baumannii is one of the most important emerging, opportunistic pathogens that can affect critical patients. Colistin, the main antibiotic effective against such bacterium, when associated with rifampicin shows an enhanced activityā€ˇ. UR - https://pharmacophorejournal.com/article/effectiveness-of-colistin-with-rifampicin-and-meropenem-against-colistin-resistant-acinetobacter-baumannii-strains-an-in-vitro-study ER -