TY  - JOUR
T1  - Formulation and Evaluation of Ziprasidone HCl Oral Controlled Release Matrix
A1  - Muhammad Mustafa Swaleh (Pharm. D)
A1  - Zeb-un-Nisa
A1  - Syed Imran Ali
A1  - Maqsood Ahmed Khan
A1  - Mehwish Rizvi
A1  - Saira Shahnaz
A1  - Rasheeda Fatima
A1  - Sadia Suri Kashif
A1  - Najeeb Khatian
A1  - Ijaz Ali
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2020
VL  - 11
IS  - 6
SP  - 41
EP  - 47
N2  - The aim of the present study was to formulate a controlled release Ziprasidone HCl oral matrix tablet using different proportions of hydroxyl propyl methylcellulose (HPMC) K15M to minimize dosing frequency. Matrix tablets were prepared with various proportions of HPMC by direct-compression to upgrade their compliance and safety profile. Micromeritic properties of blends, physical evaluation of tablets, swelling, and dissolution studies were performed to optimize the formulation. The drug release profile indicated the controlled release pattern of formulation with HPMC K15M 50% for 24 hours effectively. Ziprasidone CR matrix-based tablet was formulated successfully and it was shown that the release of drugs could be controlled by the inclusion of different ratios of various viscosity grade polymers.
UR  - https://pharmacophorejournal.com/article/formulation-and-evaluation-of-ziprasidone-hcl-oral-controlled-release-matrix
ER  -