Pharmacophore an International Research Journal
Pharmacophore
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Open Access | Published: 2012 - Issue 1

INDOLE DERIVATIVES WITH ANTICONVULSANT ACTIVITY AGAINST TWO SEIZURE MODELS Download PDF


MSY Khan, Nirmal Dhar and Asif Husain
Abstract

A series of indole derivatives (3-6 & 8a) were synthesized from 2-phenyl-1H-indole (1) with an aim to get promising anticonvulsant agents. The compounds were characterized on the basis of their IR, 1H NMR and Mass spectral data results. The compounds were tested for their anticonvulsant activity in MES and scPTZ animal models. A few compounds showed appreciable activity against both the animal models whereas one compound, 5, showed significant anticonvulsant activity and could be considered for further investigations.

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Pharmacophore
ISSN: 2229-5402


Pharmacophore
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