TY  - JOUR
T1  - METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ORLISTAT BULK DRUG USING HYDROXYLAMINE SOLUTION
BY VISIBLE SPECTROSCOPY
A1  - Alekhya Prasanna
A1  - Suman Pattanayak and K Padmalatha
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2016
VL  - 7
IS  - 1
SP  - 28
EP  - 34
N2  - A simple, precise, accurate visible spectroscopic method was developed and validated for the determination of Orlistat by using Hydroxylamine reagent and ferric chloride solution in co-solvent ethanol and subsequently diluted with distilled water. At the λmax of 515 nm, it was proved linear in the range 5-15 μg/ml, and exhibit good correlation coefficient (R2 =0.9978) and excellent mean recovery (98.82-102.3% w/w). The developed method was validated for accuracy, precision, robustness, ruggedness according to ICH guidelines. All these parameters showed adaptability of the method for the quality control analysis of Orlistat API.
UR  - https://pharmacophorejournal.com/article/method-development-and-validation-for-the-estimation-of-orlistat-bulk-drug-using-hydroxylamine-solutionby-visible-spectroscopy
ER  -