Pharmacophore an International Research Journal
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Open Access | Published: 2016 - Issue 1

METHOD DEVELOPMENT AND VALIDATION OF OXCARBAZEPINE BY USING RP-HPLC METHOD Download PDF


Varshney Neha and Thareja D.
Abstract

A simple, specific, accurate and isocratic reversed phase HPLC method was developed and validated for the estimation of oxcarbazepine. Method was achieved with an Inertsil C-18 ODS-3V column, (25cm×4.6 mm, 5μm) with mobile phase (A)- 0.1 % NH4OH in water with glacial acetic acid, (B)- acetonitrile water at the flow rate of 1.0 ml/min and at column temperature 35?C was developed. The detection was carried out using a detector set at a wavelength of 256 nm. The method was validated for accuracy, precision, linearity, specificity, stability of sample and robustness in accordance with ICH guidelines. Thus the above achieved method is suitable for estimation of oxcarbazepine.

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Pharmacophore
ISSN: 2229-5402

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