Pharmacophore an International Research Journal
The dysregulation of miR-21 has been defined as the genome instability, an event of the hallmarks of cancer, is observed in human cancers. Additionally, the effect of dysregulation of miR-21 was observed in its target genes, which is involved in many signal pathways of tumorigenesis. Among them, particularly, miR-21 is strongly involved in the anti-apoptosis processes, also known as evading apoptosis. In the present study, we studied the experimentally validated miR-21 targets, including Bcl-2, PTEN, and PDCD4 gene, which are linked to anti-apoptosis in human cancers. Thus, miR-21 and its targeting apoptosis is a valuable therapeutic target in the development of human cancer treatment.
