%0 Journal Article
%T Nano-Catalyzed Green Synthesis of Pyrazole Derivatives & Its Biological Activity as EAC Receptor Antagonists
%A Ganesh N Yallappa
%A D. Nagaraja
%A U. Chandrashekhar
%J Pharmacophore
%@ 2229-5402
%D 2019
%V 10
%N 3
%P 28-32
%X Different derivatives of Cinnamaldehydes were prepared by Claisen-Schmidt condensation (by using Strong basic reagent). The prepared Cinnamaldehydes were treated with Hydrazine hydrate in presence of ZnO Nano-catalyst under microwave assisted solvent-free conditions to afford different substituted Pyrazoles. Green chemistry was employed. Comparisons of both microwave & conventional methods were studied & found that the first was more potent than the later. The synthesized compounds were characterized by FT-IR, 1HNMR & elemental analysis. All synthesized compounds were screened for in vitro test against EAC cell lines. Most compounds exhibited good inhibitor potency with IC50 values.
%U https://pharmacophorejournal.com/article/nano-catalyzed-green-synthesis-of-pyrazole-derivatives-its-biological-activity-as-eac-receptor-antagonists