TY  - JOUR
T1  - Nano-Catalyzed Green Synthesis of Pyrazole Derivatives & Its Biological Activity as EAC Receptor Antagonists
A1  - Ganesh N Yallappa
A1  - D. Nagaraja
A1  - U. Chandrashekhar
JF  - Pharmacophore
JO  - Pharmacophore
SN  - 2229-5402
Y1  - 2019
VL  - 10
IS  - 3
SP  - 28
EP  - 32
N2  - Different derivatives of Cinnamaldehydes were prepared by Claisen-Schmidt condensation (by using Strong basic reagent). The prepared Cinnamaldehydes were treated with Hydrazine hydrate in presence of ZnO Nano-catalyst under microwave assisted solvent-free conditions to afford different substituted Pyrazoles. Green chemistry was employed. Comparisons of both microwave & conventional methods were studied & found that the first was more potent than the later. The synthesized compounds were characterized by FT-IR, 1HNMR & elemental analysis. All synthesized compounds were screened for in vitro test against EAC cell lines. Most compounds exhibited good inhibitor potency with IC50 values.
UR  - https://pharmacophorejournal.com/article/nano-catalyzed-green-synthesis-of-pyrazole-derivatives-its-biological-activity-as-eac-receptor-antagonists
ER  -