%0 Journal Article
%T QSAR AND DOCKING STUDIES OF CHLORPROPAMIDE DERIVATES
%A Teodora E. Harsa
%A Alexandra M. Harsa and Mircea V. Diudea
%J Pharmacophore
%@ 2229-5402
%D 2015
%V 6
%N 5
%P 208-219
%X A study of 40 chlorpropamide derivatives, QSAR (Quantitative Structure Activity Relationship) and molecular docking approaches were applied to explore the structural requisites of chlorpropamide derivatives for CYTOCHROME P450 2C9 inhibitory activity. A set of forty chlorpropamide, was modeled, within the hypermolecule strategy; the predicted activity was LD50 and prediction was done on similarity clusters with the leaders chosen as the best docked ligands on the CYTOCHROME P450 2C9.
%U https://pharmacophorejournal.com/article/qsar-and-docking-studies-of-chlorpropamide-derivates