Introduction and goal: Respiratory problems are the main cause of death and the most common causes of hospitalization in premature neonates in developing countries. More than 50% of the babies born under 31 weeks of gestational age will have respiratory distress syndrome (RDS), which is the cause for half of all neonatal deaths. In recent years, treatment with surfactant after birth as well as various mechanical techniques, such as using noninvasive ventilation with nasal continuous positive airway pressure (NCPAP) has improved the outcome of neonatal respiratory disease. Materials and Methods: This is a retrospective descriptive cross-sectional study that was carried out on neonates who used NCPAP device during the period of January to December 2015. Demographic data about these newborns including: gender, weight, gestational age, type of delivery, age, type of illness, duration for using the device and the final status of the newborns. The collected data were evaluated by using SPSS version 19. Results: From a total of 68 newborns with gestational age of 27-36 weeks who used NCPAP, 66% had full recovery. There was a significant relationship between the types of delivery, birth weight and gestational age with the final outcome of the newborns (P<0.05). Conclusion: Early use of noninvasive ventilation with NCPAP in preterm infants with respiratory distress at birth can be associated with a better outcome.