Diabetes mellitus (DM) is a disease that is common worldwide. The current work was conducted to assess the possible antidiabetic activity of Ipomoea batatas Leaves extract (IBLE) in streptozotocin (STZ) - induced diabetic rats. Fifty male adult albino rats were distributed to five groups (10 rats each) and were studied as following scheme for 4 weeks, group (I) normal control (cont. (-)), group (II) diabetic control rats were given distilled water daily by gastric incubation (cont. (+)), group (III) diabetic rats were treated orally with Gliclazide (GZ) (10 mg/kg), groups (IV) and (V) diabetic rats were treated orally with IBLEat (200 mg/kg) and IBLE (200 mg/kg) combined with GZ (10 mg/kg), respectively. Blood samples and pancreas were collected at the last day of the experimental period for biochemical parameters estimation as well as the histopathological examination. The IBLE administration to diabetic rats reduced significantly blood glucose (BG) level, MDA and anti-inflammatory cytokines (IL-1β and - TNF-α). On the other hand, the levels of insulin (INS), GSH and SOD were significantly increased compared with cont. (+). Moreover, the extract showed significant amelioration in pancreatic cells structure. These findings demonstrated that IBLE possess antidiabetic properties thus suggesting its beneficial effect in the DM treatment.