A 5-Years Survey on The frequency of Unexpected Antibodies in Tertiary Heart center Download PDF

Introduction: Antibodies that are present in serum but are unknown before the antibody screening test is called unexpected antibodies. Although these antibodies usually have no specific manifestations, they can cause various disorders, such as hemolytic disease of the fetus and newborn and blood transfusion reactions, in the case of need for blood transfusion. Therefore, detection of these antibodies is especially important before blood transfusion. Hence, the objective of this study was to detect unexpected antibodies in the Mazandaran heart center during five years for the first time. Methods: In this retrospective study, the investigation was carried out on the data which were available in Mazandaran heart center and Mazandaran blood transfusion organization in Sari, Iran during 2012-2017. Data included details of antibody screening and indirect antiglobulin tests results. MS Excel 2016 and SPSS 16.0 were used for statistical calculations. Results: A total of 22,527 antibody screening tests were conducted over the past 5 years. According to nine positive antibody screening tests, the frequency of unexpected antibodies was 0.04%. Positive tests included an anti-M antibody, anti-Kell antibody, anti-Fya antibody, anti-E antibody, and various autoantibodies. Conclusion: The frequency of unexpected antibodies in our healthcare center was less than those reported in different parts of the world. It is recommended that appropriate measures should be taken for the early detection of unexpected antibodies to prevent the consequences of risk factors.